In the past 15 years, fragment‐based drug discovery (FBDD) has delivered valuable starting points from the screening of relatively small sets of fragments and has been instrumental to the discovery of many clinical candidates.

Innovation against new targets remains both desirable and challenging. Towards this aim, Edelris has developed innovative fragments maximizing topological diversity, pharmacophore display and synthetic tractability (Keymical Fragments™). Arguments that support the strong interest in 3D‐fragments over traditionally flat heterocyclic structures will be illustrated by the positive results obtained on a FBLD collaborative program that led to the identification of a highly potent small molecule inhibitor of the peptidyl‐prolyl isomerase Cyclophilin‐D.

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About Edelris

Expanding the boundaries for your small molecule drug discovery! 

Edelris is a leading Drug Discovery CRO, providing Compound Libraries, Organic & Medicinal Chemistry, High Throughput Screening, and Analytical expert services to the Pharmaceutical, Cosmetic, Crop Protection, and Biotech sectors.

Cross-fertilizing our combined experiences, knowledge, and techniques, together we break through to successful solutions for you.