News

News

Nov062017

European Lead Factory : Learnings & Achievement Meeting 2017

We showcased the strategy put in place within Edelris to meet the target of delivering 40K innovative compounds to the ELF Public Compound Collection. By using the Lean Six Sigma approach we were able to significantly improve our production tool, enabling us to reallocate effort to solving other demanding problems such as scaffold validation and additional value adding tasks. Key Performance Indicators have been shared and discussed.

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Sep192017

EFMC ASMC 2017 – Results from our collaboration with Merck

EDELRIS had the opportunity in August 2017 to present the work carried out in collaboration with Merck. This collaboration is a perfect example of the relevance and complementarity of EDELRIS’ Services.

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Jul212017

Edelris is looking for talented organic/medicinal chemists

We are a leading Drug Discovery CRO for Life Sciences Organizations, providing expert Organic High-Throughput, Medicinal Chemistry services...

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Jul032017

RICT in Toulouse

Edelris will give a presentation on "Mining from NP-Like Fragments in 3D: Discovery of a Potent Caspase-1 Inhibitor"

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Jun122017

WPC Mastering Medicinal Chemistry (Boston, June 15th)

Edelris will present positive results obtained with 3D fragments on Cyclophilin-D

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Apr102017

The Annual Meeting 2017 American Association for Cancer Research

Our partner Bayer HealthCare presented interesting results from a collaboration with EDELRIS at the Annual Meeting AARC in Washington.
This study case concerns a service of hit to lead on an epigenetic regulator: ATAD2. The work carried out by EDELRIS EDELRIS improved the affinity, selectivity and diffusion in tissues from Hits initially identified from a DNA-encoded compound libraries.

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Mar172017

ACS 2017 (San Francisco)

EMD-Serono will reveal new results on Cyclophilin-D inhibitors originating from Edelris 3D-fragments

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Jan312017

Research Collaboration Agreement signed with Pfizer Inc.

Edelris s.a.s., a leading medicinal chemistry company focused on applying its EDEN (Edelris Discovery ENgine) technology [...]

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Jan122017

Edelris is looking for talented organic/medicinal chemists

Designing and perfoming innovative molecule syntheses with a strong therapeutic potential

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Sep092016

FBLD Boston 2016

Edelris will present positive results obtained with 3D fragments on Cyclophilin-D

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Sep082016

FBLD Boston 2016

Mining from NP-Like Fragments in 3D: discovery of a Potent Caspase-1 Inhibitor presented by Edelris

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Aug242016

SAHOC2016: [5+2]-Cycloaddition reactions for the generation of diverse 3D-scaffolds and library synthesis

Cycloaddition reactions are highly useful tools to address 3D-rich and functionalized scaffolds. This presentation will show the successful applications of [5+2]-cycloaddition reactions to access library scaffolds containing seven-membered rings. The chemistries were validated by the University of Leeds scientists and after transfer of knowledge to our scientists at EDELRIS, up-scaling and final library syntheses were effectively performed. Hurdles, solutions and outcomes will be discussed.

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Aug232016

Unprecedented inhibitors of the ATAD2 bromodomain from a DNA-encoded chemical library screen

On the occasion of the 5th International Symposium on DNA-encoded chemical libraries (Zürich, August 26, 2016), Bayer AG discloses a poster co-authored by X-Chem and Edelris, and describing the discovery of BAY-850, a selective ATAD2 small molecule inhibitor, underscoring the value of DNA-encoded chemical libraries to address difficult-to-drug targets (soon to be published).

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Jul122016

[3+2]-Cycloaddition reaction: Synthesis of Libraries of Drug-Like pyrrolidine scaffolds

The [3+2]-cycloaddition reaction is a powerful tool to address 3D-rich and highly functionalized scaffolds for chemical library development. Applying this methodology, two diverse pyrrolidine containing scaffolds were designed. The in situ generated nitrone was reacted with N-Boc 2,5-dihydro-1H-pyrrole and its analog. The obtained isoxazolidine cycloaddition adducts were reduced and functionalized, leading to multiple entry points for diversity generation. Two 500-compound libraries were synthesized, validating the concept.

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Jun282016

Scaffold Hopping from Complex 3D Fragments

There is a strong interest for the discovery of novel inhibitors of Caspase-1 (ICE), a protein involved in various inflammatory diseases such as rheumatoid arthritis, osteoarthritis or psoriasis. In order to develop new inhibitors, we used our EDEN platform (Edelris Discovery ENgine) to successfully explore the possibility to rescaffold competitor's ligands from innovative, 3D-enriched Keymical FragmentsTM.

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